How to Layer Peptide, PDRN, Retinal and NAD+ Serums

Layer NAD+ first and PDRN second in the morning, then finish with moisturiser and SPF. In the evening, apply PDRN first, peptide second and retinal last, followed by moisturiser. This order follows each serum’s designated use: NAD+ is an AM serum, PDRN suits AM or PM use, while GHK-Cu and retinal are PM serums. Apply each serum to clean, dry skin, allow it to settle, then move to the next step. Keep the routine consistent rather than adding every active at once.

The simple layering order: morning and evening

The most straightforward way to layer peptide, PDRN, retinal and NAD+ is to divide them between morning and evening. In the morning, use NAD+ first, then PDRN, followed by moisturiser and broad-spectrum SPF. At night, use PDRN first, peptide second, then retinal, and complete the routine with moisturiser. This structure keeps NAD+ in its designated AM slot and reserves both peptide and retinal for PM use. PDRN provides the flexible step because it is designed for AM and PM application. Begin every routine with clean, dry skin. Apply one serum at a time in a light, even layer rather than mixing products together in your palm. Let each layer settle before applying the next. A clear order makes it easier to maintain a routine and notice how your skin looks and feels over time.

Morning order: NAD+ followed by PDRN

Morning is the place for NAD+ and PDRN. After cleansing, apply your NAD+ serum first, then apply PDRN. The Renoviq London NAD+ — Cellular Energy Serum contains 3% nicotinamide riboside and is designated for AM use. PDRN — Polynucleotide Repair Serum contains 3% polynucleotides and is suitable for AM or PM use, so it fits neatly after NAD+ in this routine. Follow with moisturiser, then use SPF as the final daytime step. Keep the sequence the same each morning: cleanse, NAD+, PDRN, moisturiser, SPF. This avoids moving products between different stages every day. If you use additional non-serum skincare, keep the serum steps together after cleansing and before your final moisturising and sun-protection steps. The aim is a practical routine that is simple to repeat.

Evening order: PDRN, peptide, then retinal

At night, layer PDRN first, peptide second and retinal third. Start with clean, dry skin, then apply PDRN. Follow with a copper peptide serum, then use retinal as the final serum step before moisturiser. Renoviq London GHK-Cu — Copper Tripeptide Firming Serum contains 3% copper tripeptide-1 and is designated for PM use. RETINAL — Overnight Renewal Serum contains 0.1% retinaldehyde and is also designated for PM use. This gives a clear placement for every serum without putting NAD+ into the evening routine. Applying retinal last keeps the evening sequence easy to follow: PDRN, GHK-Cu, retinal, moisturiser. Use a modest amount of each product and avoid over-layering. A consistent evening order supports a polished skincare ritual focused on the look of smoother, more radiant-looking skin.

How to keep a four-serum routine manageable

A four-serum collection does not require four serum layers in every routine. The most efficient approach is two serums in the morning and three in the evening, with PDRN appearing in both because it is designated for AM and PM use. NAD+ stays in the morning, while peptide and retinal stay in the evening. This division is easier to remember than rotating every product daily. Keep your application method calm and consistent: cleanse, apply the first serum, let it settle, then continue in order. Finish with moisturiser, plus SPF in the morning. If you are building a new routine, establish the sequence before adding extra skincare steps. Write the morning and evening order down if needed, especially during the first few weeks. Consistency matters more than using a large amount of any one serum. The result is a routine with a clear purpose at each stage and no uncertainty about what comes next.